Highlights
- Curcumin was prepared as a polymerized Nano-formulation to increase its bioavailability.
- Polymerized nano-curcumin (PNC) reduced the EAE symptoms.
- PNC reversed EAE-induced changes in the expression of pro-inflammatory, anti-inflammatory and oxidative stress marker genes.
- PNC improved remyelination and increased progenitor cell markers in spinal cord of EAE rats.
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