Highlights

• Curcumin was prepared as a polymerized Nano-formulation to increase its bioavailability.
• Polymerized nano-curcumin (PNC) reduced the EAE symptoms.
• PNC reversed EAE-induced changes in the expression of pro-inflammatory, anti-inflammatory and oxidative stress marker genes.
• PNC improved remyelination and increased progenitor cell markers in spinal cord of EAE rats.